While both LATE and Alzheimer’s lead to progressive memory loss, LATE occurs later in life in the 80s while Alzheimer’s becomes more common after 65. LATE also involves the buildup of the TDP-43 protein in the brain’s memory hub, the hippocampus, while Alzheimer’s involves a buildup of beta-amyloid plaques and tau tangles. LATE progresses more slowly than Alzheimer’s but it is very common for these diseases to co-occur, leading to faster decline.