Currently, there is no definitive biomarker or test available to diagnose LATE in living patients. Doctors could use biomarker testing to exclude the possibility of Alzheimer’s and look at brain scans for scarring of the hippocampus. Scientists are currently developing a cerebrospinal fluid test that detects elevated levels of cryptic HDGFL2 that may precede the disease, and a brain scan algorithm called MARBLE that shows 76% accuracy rate in spotting LATE. These biomarkers still require more testing and validation.