• If people with Alzheimer’s have earlier displays of behavioral changes, then how much do we know about where behavior is controlled inside the brain?

• What are the earliest verbal signs of brain disease?

• Is there evidence out there that behavioral strategies do indeed work?

• Do personality and behavioral changes become noticeable around the same time that biomarkers, such as the plaques and the tau tangles, become detectable?

• Is it important to have the same routine, give the patient the same expectations? Does that help with behavior?

• What is happening inside the brain to change behavior?

• What does stress do to the brain?

• Is social engagement important?