Though Alzheimer’s and FTD are both neurodegenerative diseases, the symptoms and the proteins that accumulate in the brain are different. Alzheimer’s often starts with memory loss and thinking problems while FTD may involve changes in language, behavior, personality, and movement. FTD affects people decades earlier than Alzheimer’s, with onset often starting between 40 and 65 years of age, and instead of a buildup of beta-amyloid plaques and tau tangles in the brain, there is a variety of protein aggregates like TDP-43, FUS, TAF-15, and tau that may buildup.